Objectives: The purpose of this study was to get help in order to diagnose orthopaedic disease, measure its activity and determine treatment plan by measuring the -glucuronidase activity in urine, serum and joint fluid.
Methods :The -glucuronidase activity was determined in the serum, urine and joint fluid of the patients with degenerative arthritis, rheumatoid arthritis, osteomyelitis and osteogenic sarcoma, and some other disease -to study the change of the enzyme activity. These values of each specimen were calculated by standard curve and treated by statistical analysis.
Results : The results obtained were summarized as follows.
1.The -glucuronidase activity in the serum, urine and joint fluid was increased in patients with degenerative arthritis, rheumatoid arthritis, osteomyelitis and osteogenic sarcoma etc.
2. he increased -glucuronidase activity in the serum and joint fluid of each disease does not show a specific finding about respective disease, but the increased -glucuronidase activity was statistically significant in the urine of all disease groups (male: p4). 0041, female: p0.0001) .
Conclusions : On the basis of these results, it was suggested that R-glucuronidase activity was affected by the orthopaedic disease and differed according to each specimen.
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